Formulation Development and Evaluation of Ondansetron Hydrochloride Nasal Spray

The objective of the present study was to formulate and evaluate nasal delivery system contains Ondansetron hydrochloride 4 mg/ml. Ondansetron hydrochloride loaded colloidal dispersion were prepared for nasal drug delivery using various polymers like β-cyclodextrin, hydroxyl propyl βcyclodextrin at different concentrations. The optimized formulation contains 0.02% benzalkonium chloride as a preservative, 0.02% of disodium EDTA as an antioxidant, 1.36% of potassium dihydrogen phosphate and 3.58% of disodium hydrogen phosphate mixture was used as a buffer to maintain the pH of the formulation. The finished formulation was characterized for its clarity, pH, viscosity, drug content, pka, pump delivery, net content, weight loss on storage, in vitro diffusion and in vitro bioadhesive strength. Therefore a nasal delivery system of Ondansetron hydrochloride which was developed and formulated in this study is ideal for nasal administration for the treatment of antiemetic.